Through 1990âs to 2000âs, world scientists found several 3âUTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Recently we have also found evidence that the independent C/EBP 3âUTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Recently, an AU-rich region in the C/EBP 3âUTR was found also to be responsible for its tumor suppression. Then, the C/EBP 3âUTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Also, it was shown that the sequences near the termini of the C/EBP 3âUTR were important for its tumor suppression activity. Our subsequent studies showed that transfection of C/EBP 3âUTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Since 1991, we found that the middle part of the 3âUTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. The importance of independent 3âUTR RNA (referred as I3âUTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. However, there exists another kind of RNA, which consists of the 3âUTR alone, without all other elements in mRNA such as 5âUTR and coding region. It is transcribed as an integral part of the mRNA encoded by the gene. Maintaining motile cells inside the biofilm through cell-to-cell signaling, transcription regulation and evolutionĬlassically, the 3âuntranslated region (3âUTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. SLUG and SOX9 Cooperatively Regulate Tumor Initiating Niche Factors in Breast Cancer Wei Gong-Huazhong-University-of-Science-and-Technology-China-Probabilistic-seismic-hazard-assessment-for-the-pseudo-negative-stiffness-control-of- a-steel-base-isolated-building-A-comparative-study-Įffect of ciprofloxacin and levofloxacin alone or in combination with N-acetylcysteine on biofilm-producing Enterococcus faecalis: Contaminated root canals of extracted human teethĮxamining the Social and Physical Environment of Adolescent Substance Users in Shanghai and East BaltimoreĮffect of Calcium Antagonists on Insulin Releaseīioprocess Development Upstream and Downstream Technologies Tilita-George-Alexandru-Hong-Kong-University-of-Science-and-Technology-Hong-Kong-SAR-China-The-effect-of-individual-input-parameters-on-the-development-of-imperfections-during-selectiveĬhen-Wenhao-Hong-Kong-University-of-Science-and-Technology-Hong-Kong-SAR-China-An-integrated-model-for-dendrite-growth-simulation-in-selective-laser-meltingĪdvances in Internet of Things and Cyber Physical Systems and its Adoption to Smart Ship

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